What is the Fasting Mimicking Diet (FMD)?

The first and only patented nutrition program to support healthy aging through cellular rejuvenation

The Fasting Mimicking Diet (FMD) is a revolutionary five-day nutrition program scientifically formulated to mimic the effects of a prolonged water fast while still allowing nourishment - supporting the benefits of fasting without the challenges and risks that come from water-only fasts.
47
Clinical trials on the use of fasting mimicking nutrition.
200+
Issued or pending patents globally on fasting mimicking nutrition.
18
Prestigious University partners in the testing and research of FMD.
100M
In funding received to support research and development.
"Autophagy ends with a full reprogramming of new cells. When you reprogram, you are impacting the DNA. We are reprogramming the cells to behave younger."
- L-Nutra’s CEO, Dr Joseph Antoun MD, PhD.
How does FMD work?
Each day of the Prolon fast is carefully formulated to activate your body's natural cell-rejuvenating processes. The five days build upon one another to trigger the various stages of fasting that contribute to cellular renewal, so each day has its own unique and important role in that process.
Typically by day 2 the body enters ketosis, burning fat for fuel, and by day 3, autophagy kicks in. As your body's natural process of recycling or removing damaged cells, autophagy is like a deep, internal spring cleaning - and will continue working throughout the rest of your fast (even going until two days after it’s completed).. However, the FMD’s effects may go beyond autophagy to support complete cellular reprogramming.
Phase 1: Autophagy (Rejuvenation)
Autophagy, the first phase of rejuvenation, begins around day 3 of the FMD. During this process, the body clears out damaged cellular components, recycling essential materials and preparing for renewal.
Phase 2: Cellular Reprogramming
Following autophagy, new, healthier cells emerge, reprogrammed to function more efficiently. This cellular reset impacts DNA, promoting a youthful cellular profile that can support healthy aging and a healthy immune system.
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How to use Prolon FMD
Everything you need for each day of the fast is included in your kit. Each day’s nutrition is scientifically formulated to stay below nutrient sensing pathways, and should be followed precisely to ensure the body enters and remains in a fasting state.

While even a single cycle of Prolon 5-Day offers numerous benefits, each builds upon the last. We recommend an initial three-month cycle for optimal impact (15 days over 90), followed by three to four cycles yearly to maximize results (about once each quarter).
What's inside the Prolon kit
Inside your kit, you receive individual boxes for each day of the fast with everything you need, including bars, soups, supplements, snacks, and teas. All these foods are scientifically formulated to provide essential nutrients while staying below nutrient-sensing thresholds, helping your body to enter a fasting state and activate beneficial processes like ketosis and autophagy.
Start Your Journey with Prolon
Experience the scientifically proven way to receive the rejuvenating effects of fasting while receiving essential nutrition. Thousands have already discovered the power of Prolon’s FMD—science-backed and designed for real results.
SHOP PROLON
The creator of Fasting Mimicking Technology - Dr. Valter Longo, Ph.D
Dr. Valter Longo, Director of the Longevity Institute at the University of Southern California, was recognized by TIME as one of the top 50 most influential people in health. As the pioneering mind behind the Fasting Mimicking Diet, Dr. Longo was awarded the first-ever patent for Healthspan. His groundbreaking work revealed how cells sense nutrients, leading him to develop the FMD formulation. Through extensive mouse and human trials, he demonstrated the powerful benefits of this approach. These discoveries are the foundation of our Prolon product line, designed to bring the science of healthy aging to you.