Path to Healthspan: The Life-Changing Science Behind Cellular Rejuvenation


Supporting healthspan through cellular rejuvenation.

Our on-going commitment to extending healthspan through rigorous research drives us to explore innovative, clinically-backed ways to support health and longevity. At the core of Prolon products lies the science of Fasting Mimicking Nutrition Technology—a breakthrough designed to deliver the extensive health benefits of fasting, while still nourishing the body with scientifically formulated foods.

Developed over 25 years in collaboration with the Longevity Institute at the University of Southern California and L-Nutra Inc., Prolon's 5-Day Fasting Mimicking Diet (FMD) has transformed fasting into a scientifically-backed, food-based approach to longevity.

This clean, plant-based nutrition protocol supports the body's metabolism and cells in fasting mode, tapping into autophagy and enabling cellular rejuvenation. With $48 million in funding and rigorous testing through 32 clinical trials at 18 globally renowned institutions — including Stanford, Mayo Clinic, University of Miami, and University of Genoa, and more — Prolon’s Fasting Mimicking Nutrition has gained recognition for its contributions to the field of Food as Medicine.

Notably, these trials have shown that completing three to six cycles of the Prolon FMD each year can lead to profound health benefits, including reduced biological age score, fat-focused weight loss with muscle preservation, healthy metabolic markers, and more
Benefits of Prolon

Grounded in Rigorous Science

Prolon’s science is built upon five foundational pillars, as defined by Dr. Valter Longo, one of the world’s leading longevity experts:


Juventology
Research


This study of youth begins with preclinical research in animal models to examine the potential of diet to extend longevity.

Epidemiological
Research


By understanding disease risk factors within populations, we can further test and validate hypotheses arising from our research.

Clinical
Studies


Through randomized, controlled trials, we evaluate the effectiveness and safety of our strategies in human subjects.

Centenarian
Studies


Research with centenarians helps us assess the long-term benefits of fasting-based nutrition strategiesResearch with centenarians helps us assess the long-term benefits of fasting-based nutrition strategies.

Complex Systems
Analysis


By modeling the intricate interactions between food, cellular damage, and aging, we aim to unravel the complex mechanisms of longevity and metabolic health.

Through these pillars and ongoing clinical trials, Prolon's Fasting Mimicking Technology remains at the forefront of the nutrition and longevity fields, illustrating how strategic fasting-based nutrition can support healthier, longer lives.

Most Read Articles & Studies


NATURE

The New Champion of Health Programs: How the Fasting Mimicking Diet Surpasses the Mediterranean Diet

A groundbreakign study in Nature compares the benefits of Prolon vs the Mediterranean Diet for over 120 days.
Article
NATURE

Could You Live Longer and Healthier by Reducing Your Biological Age

The harsh truth? Aging is inevitable. The prospect of wrinkles, fading energy, and the gradual decline of physical and mental abilities is enough to make anyone wish for a pause button on the relentless ticking clock.
Article

Explore a selection of scientific and medical publications on the FMD and Fasting Mimicking Technology below:


A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy
A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy
Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk
Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease: controlled trial
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease: controlled trial
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan
Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial
Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial
Fasting Mimicking Diet Cycles vs a Mediterranean Diet and Cardiometabolic Risk in Overweight and Obese Hypertensive Subjects: A Randomized Clinical Trial
Fasting Mimicking Diet Cycles vs a Mediterranean Diet and Cardiometabolic Risk in Overweight and Obese Hypertensive Subjects: A Randomized Clinical Trial
The Effects of a Fasting Mimicking Diet on Skin Hydration, Skin Texture, and Skin Assessment: A Randomized Controlled Trial
The Effects of a Fasting Mimicking Diet on Skin Hydration, Skin Texture, and Skin Assessment: A Randomized Controlled Trial
Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study
Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study
Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial
Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial
Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality
Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality
An Intermittent Fasting Mimicking Nutrition Bar Extends Physiologic Ketosis in Time Restricted Eating: A Randomized, Controlled, Parallel-Arm Study
An Intermittent Fasting Mimicking Nutrition Bar Extends Physiologic Ketosis in Time Restricted Eating: A Randomized, Controlled, Parallel-Arm Study
Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis
Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis
Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan
Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan
Fasting and cancer treatment in humans: A case series report
Fasting and cancer treatment in humans: A case series report
Fasting-mimicking diet and hormone therapy induce breast cancer regression
Fasting-mimicking diet and hormone therapy induce breast cancer regression
Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence
Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence
Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology
Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
Prolonged Fasting reduces IGF-1/PKA to promote hematopoietic stem cell-based regeneration and reverse immunosuppression
Prolonged Fasting reduces IGF-1/PKA to promote hematopoietic stem cell-based regeneration and reverse immunosuppression
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms
Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control.
Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control.

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