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THE PROLON LONGEVITY PROGRAM
To live longer, treat aging first
The Longevity Program is designed to support cellular renewal and a healthier metabolism. Slow down everyday aging and temporarily reverse it, so you can feel stay younger than your age.
40+
clinical
trials
130
issued
patents
18+
Global university
partners
25+
years of longevity
research9
Peer-reviewed and published in
WHY TREAT AGING?
Aging is what limits you
The greatest threat to your long-term health isn’t any single condition—it’s aging itself. Aging is the biggest risk factor for heart disease, diabetes, cancer, and Alzheimer's. Slowing it down is how you can live healthier, longer.
Aging impacts you every day: emotionally, physically, and medically
1
How you feel
Energy. Stamina. Focus. Sleep. Brain fog. Mood. Vibrance. Confidence. Happiness.
2
How your body changes
Stubborn weight gain. Muscle loss. Fatigue. Libido. Performance. Stress.
3
How your health shifts
Blood Pressure. Blood sugar. Diabetes. Cholesterol. Triglycerides. Inflammaging.
how it works
How does the Longevity Program keep you younger than your age?
It slows down everyday aging, and temporarily reverses it.
Slow your aging every day with the six pillars of longevity
Every month, the program includes an exclusive, expert-led curriculum on a key pillars of longevity. Your dedicated, registered Longevity Dietitian then tailors a longevity lifestyle plan to your blood work and health goals.
- Nutrition and fasting
- Exercise
- Sleep
- Stress
- Connection
- Environment
What's included
Everything you need to take on aging, in one program
Longevity experts
Your own Longevity Dietitian, with supervision from physicians, guiding you every month.
Longevity biomarkers
Your blood work, reviewed with your Longevity Dietitian, so you can see your aging biomarkers move.
Longevity interventions
Your 5-Day FMD Protocol, plus precision nutrition built around your plan.
Longevity education
Your Prolon app, an AI-powered digital platform, plus a live class with a longevity expert every month.
Your longevity program, in your pocket.
The Prolon app is an AI-powered digital platform. Watch your aging biomarkers move, as real numbers. Message your Longevity Dietitian, book sessions, and sync Apple Health. Quick question at midnight? Ask Prolon AI, trained by our Longevity Dietitians, anytime.
who it's for
Over 40 and feeling your age? It's time.
- This is for you if you're:
- Navigating menopause
- Wanting your energy, strength, and stamina back
- Wanting your energy, strength, and stamina back
-
Watching your checkup numbers creep up
If you want to feel like yourself for decades to come, this program is for you.
Start treating aging todaywhy l-nutra
From the global leader in longevity nutrition
-
Founder of L-Nutra
Valter Longo, PhD
Creator of the Fasting Mimicking Diet, and one of TIME's 50 most influential people in health.
-
Chief Executive Officer
Dr. Joseph Antoun, MD, PhD, MPP
CEO of L-Nutra. Launched the first longevity fund and the first longevity product.
-
Chief Medical Officer
Dr. William Hsu, MD
Former VP of Harvard's Joslin Metabolic and Diabetes Center. Leads clinical care.
-
Director of Clinical Nutrition and Global Training
Ashley Bizzell, RD, LDN, CDCES
Director of Clinical Nutrition and Global Training. Specializes in metabolic health and lifestyle-informed nutrition, and heads member protocol design.
MEMBERSHIP
Starting at $99 a month
Or add the 5-Day FMD Protocol three times a year for $149 a month
LONGEVITY PROGRAM
Guided
Your Longevity Dietitian, your labs, your plan.
$99/month
plus a one-time $99 signup fee
- Your Longevity Dietitian: a 45-minute first session, then a private 30-minute session every month, and a direct line to them in between
- Baseline and follow-up labs
- Members-only live sessions with renowned longevity experts, every month
- The Prolon app, an AI-powered digital platform: book sessions, message your Longevity Dietitian, and ask AI
- Member pricing across Prolon products
LONGEVITY PROGRAM
Guided + Protocol
Everything in Guided, plus the Prolon 5-Day.
$149/month
plus a one-time $99 signup fee
- Your Longevity Dietitian: a 45-minute first session, then a private 30-minute session every month, and a direct line to them in between
- Baseline and follow-up labs
- Members-only live sessions with renowned longevity experts, every month
- The Prolon app, an AI-powered digital platform: book sessions, message your Longevity Dietitian, and ask AI
- Member pricing across Prolon products
- The Prolon 5-Day Fasting Mimicking Diet, about three times a year
- Cycle timing and prep with your Longevity Dietitian
CLINICAL CARE, BY ELIGIBILITY
Cardiometabolic Care
$249/month
Diabetes Care
$299/month
- Everything in Guided + Protocol tier
- Your Longevity Dietitian, twice a month
- Cardiometabolic Care: led by your Longevity Dietitian, with updates shared with your primary care physician.
- Diabetes Care: telehealth visits with Lifestyle Medicine physicians, with supervision led by Dr. William Hsu
Start with Guided + Protocol. Your Dietitian reviews your labs first and recommends the right program.
The Longevity Program isn't available in New York, New Jersey or Rhode Island at this time. Manage, change, or cancel your membership anytime from Account > Program in the app or on your account login.
clinical care, by eligibility
Need more clinical support? Explore our more personalized programs.
For type 2 diabetes or cardiometabolic risk: your Longevity Dietitian twice a month and 5-Day FMD cycles. Diabetes Care adds telehealth visits with Lifestyle Medicine physicians, with physician-led supervision. Cardiometabolic Care keeps your primary care physician updated. Alongside your usual care, never instead of it.
The clinical results behind these programs
53% vs 8%
improved glycemic management with monthly FMD cycles plus usual care, vs usual care alone, in a 12-month randomized trial1
8.1% → 6.7%
average HbA1c after six monthly cycles, in a 6-month randomized pilot2
−4.1 mmHg
average drop in systolic blood pressure (−2.3 mmHg diastolic), across 11 randomized trials3
Questions, answered.
How does the program work on aging?
Every day, through habits built around the six pillars of longevity. In Guided + Protocol, the 5-Day FMD Protocol also triggers autophagy, your body's natural cellular cleanup, as shown in humans. Your Longevity Dietitian reviews your blood work with you to track your biomarkers over time. Autophagy results come from clinical studies of the 5-Day FMD Protocol, included in Guided + Protocol.
What is the Prolon Longevity Program?
The first program to bring together everything it takes to treat aging: supervision by longevity experts, your blood work reviewed with your Longevity Dietitian, the 5-Day FMD Protocol, and the Prolon app, an AI-powered digital platform. It slows down everyday aging and reverses it, so you can be younger than your age.
What happens after I join?
You're paired with your Longevity Dietitian, a registered dietitian trained in the Longevity Diet who stays with you through your membership. You start with a 45-minute session and baseline labs at a Labcorp near you, and build your plan together. After that, each month brings a private 30-minute session and a live session with a renowned longevity expert. In between, message your Longevity Dietitian for a reply within 24 hours, or ask Prolon AI in the app anytime.
What's the difference between Guided and Guided + Protocol?
Guided gives you your Longevity Dietitian, your labs, and a plan built with you. Guided + Protocol adds the 5-Day FMD Protocol about three times a year: five days of plant-based food, so you eat throughout. When your box arrives, hold off until you've met your Longevity Dietitian, who'll help you pick a start date.
Do I need blood work?
Yes, and it's included in both Guided and Guided + Protocol. You start with a baseline panel at a Labcorp near you, covering a metabolic panel, a lipid panel, and IGF-1, then get follow-up labs to see what's changed. Your Longevity Dietitian walks you through every result.
I've done the Prolon 5-Day before. What's different here?
You already know the five days. The membership is about everything around them: labs that show where you're starting, a Longevity Dietitian who plans the weeks in between with you, and monthly expert sessions on sleep, movement, stress, and more.
Can my plan fit how I eat?
Yes. Your Longevity Dietitian builds your meal plan around you, whether you eat vegan, vegetarian, gluten-free, or something else, and makes sure you're getting enough protein. After each 5-Day FMD Protocol, they'll help you ease back into eating, too.
How does the app fit in?
The Prolon Longevity Program app is home base: your plan, sessions, messages, and reminders all live there, so turn on notifications when you set it up. Connect Apple Health and your Longevity Dietitian sees your sleep and activity data.
How is this different from a dietitian through my insurance?
Insurance-covered dietitians usually focus on treating one condition. Your Longevity Dietitian plans for the long run, with labs included, a clinically tested nutrition protocol¹ ⁵, and monthly expert sessions.
Are there side effects?
In clinical studies, side effects were generally mild and temporary, such as weakness or headache on fasting days.² ⁵ If you take glucose-lowering medication, your care team guides any adjustments.
How do the clinical programs work?
If your labs indicate type 2 diabetes or cardiometabolic risk, your Longevity Dietitian may recommend a clinical program based on your labs, health history, and program criteria. A physician then reviews your results and makes any diagnosis. Eligibility is a clinical decision. Clinical programs complement your existing care; any medication changes are made by a physician.
Can I cancel or change tiers?
Yes. Manage, change, or cancel your membership anytime from Account > Program in the app, which opens your subscription settings. Your Longevity Dietitian or our support team can help. The signup fee is only charged once, so changing tiers won't add it again.
The Longevity Program Guided and Guided + Protocol tiers are wellness programs and do not diagnose or treat any disease. Diabetes Care is provided under physician supervision. Cardiometabolic Care is led by registered dietitians, in coordination with each member's primary care physician. Individual results vary. Study results describe trial participants, not guaranteed program outcomes. Patient stories are from L-Nutra Health clinical programs; results are not typical or guaranteed, and medication changes were made only by each patient's physician. Energy and focus are user-reported, after the fast. Pricing for hospital clinics per reference 4.
References
- van den Burg EL, et al. Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial. Diabetologia. 2024;67:1245-1259.
- Sulaj A, et al. Six-month periodic fasting in patients with type 2 diabetes and diabetic nephropathy: a proof-of-concept study. Journal of Clinical Endocrinology and Metabolism. 2022;107:2167-2181.
- Mohammadzadeh M, et al. Impact of fasting mimicking diet (FMD) on cardiovascular risk factors: a systematic review and meta-analysis of randomized control trials. Diabetology and Metabolic Syndrome. 2025;17:137.
- Zimmerman E. Is longevity medicine going mainstream? The New York Times. October 16, 2026.
- Wei M, et al. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science Translational Medicine. 2017;9:eaai8700.
- Maloh J, et al. The effects of a fasting mimicking diet on skin hydration, skin texture, and skin assessment. Journal of Clinical Medicine. 2023;12:1710.
- Espinoza SE, et al. Effect of fasting-mimicking diet on markers of autophagy and metabolic health in human subjects. GeroScience. 2025.
- Energy and focus are user-reported by Prolon customers after completing the fast; not a measured clinical outcome.
- Brandhorst S, et al. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nature Communications. 2024;15:1309.