Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial
Eur J Appl Physiol, 2022. Nardon M, et al.
Funding and competing interests (as published with the paper): Conflict of interest: VDL has equity interest in L-Nutra, a company that develops medical food. All other authors have no conflicts of interest to declare that are relevant to the content of this article. Funding: This research was funded in part by the Create Cures Foundation.
- Study type
- Human clinical trial (randomized, n=24)
- Journal
- Eur J Appl Physiol
- Published
- 2022
- Authors
- Nardon M, et al.
- DOI
- 10.1007/s00421-021-04867-2
- PubMed ID
- 35034194
Summary
Twenty-four physically active, healthy young men were randomly assigned to three consecutive monthly cycles of a Fasting Mimicking Diet (FMD) or to a normal diet. Researchers measured muscle force production, muscle volume and body measurements at the start, after the first cycle, and about a week after the third cycle.
The authors reported a significant drop in body mass after the first FMD cycle compared with the normal-diet group, but no change or difference between groups in measures of muscle force production or muscle volume, including when adjusted for muscle size.
This trial covered only healthy young men over three cycles; the authors note that further research is needed in groups at higher risk of muscle loss, such as older or obese adults with sarcopenia, before extending the finding to those populations.
A randomized trial in 24 healthy, physically active young men.
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