Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan
Nat Metab, 2021. Mishra A, et al.
Funding and competing interests (as published with the paper): Competing interests: V.D.L. has equity interest in L-Nutra, which develops and sells medical food for the prevention and treatment of diseases. V.D.L. has committed all his equity in the company to charitable organizations. All other authors declare no competing interests. Funding: Funding was provided by the USC Edna Jones chair fund and NIH P01 AG055369-01 to V.D.L. This work was also funded, in part, by the Intramural Research Program of the National Institutes of Health/NIA. We acknowledge support from the USC Molecular Imaging Center and the USC Leonard Davis School Aging Murine Phenotyping Core Facility. A. Mouton was supported by a QCB Collaboratory Postdoctoral Fellowship (UCLA).
- Study type
- Animal study (mice)
- Journal
- Nat Metab
- Published
- 2021
- Authors
- Mishra A, et al.
- DOI
- 10.1038/s42255-021-00469-6
- PubMed ID
- 34650272
Summary
Researchers fed female mice a high-fat, high-calorie diet for two years, giving some of the mice a 5-day Fasting Mimicking Diet (FMD) every four weeks, to see whether periodic FMD cycles could offset the effects of the high-fat diet.
The authors reported that FMD cycles reduced visceral and subcutaneous fat accumulation without loss of lean body mass, increased blood vessel density and function in the heart, helped prevent high blood sugar, high cholesterol and impaired glucose and insulin tolerance caused by the high-fat diet, and were associated with changes in fat-cell gene activity and sustained ketosis.
This is a mouse study only; the diet, dosing schedule and two-year timeframe were designed for mice, not people, and the cardiometabolic and lifespan findings have not been shown in a human trial. This study does not show that an FMD produces these effects in people.
A study in female mice only. The findings have not been shown in people.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
