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Prolon L-Biome

Gut Health
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Suggestions for use

DIRECTIONS: For adults, take two (2) capsules daily, preferably with a meal.



The L-Biome could be used daily by anyone aged 18-80. Best use is to take after doing one of ProLon’s Fasting Nutrition Products: 5 Days Fasting Mimicking Diet, One Day Reset Nutrition, Fast Bar or Fasting Shake. You can stop and restart at any time of your liking. If you have a health condition, consult with your doctor before taking the L-Biome. Do not take the L-Biome if you have allergies to any of its ingredients.
Supplements Facts

Prolon is eligible for purchase and reimbursment wiht HSA/FSA — partnered with TrueMed. Questions? Learn more

Gut health is essential to a vibrant life. L-Biome will support your journey star
HOW TO USE

Ingredients for optimal gut health

Research has demonstrated the beneficial effects of prolonged fasting programs on the microbiome, fostering the growth of beneficial microbes. The L-Biome product integrates prebiotic fiber and two essential probiotics, mirroring the post-fasting microbiome. In alignment with our ethos at Prolon, the L-Biome also incorporates DHA to support the healthy aging of various organs and systems.

Morinaga B-3®

Morinaga B-3 Bifidobacterium, which, besides its gut health benefits, has been shown to support weight, body fat percentage, blood glucose, and cholesterol levels already within a normal range. This is one of the essential microbiota that flourishes post Prolon Fasting Nutrition.

LactoB™

LactoB HN001 supports healthy digestive and bowel function, promotes healthy gut barrier integrity, supports healthy gut-immune axis, and encourages digestive comfort and healthy nutrient absorption. This is one of the essential microbiota that flourishes post Prolon Fasting Nutrition.

Chicory Root Prebiotic

L-Biome also contains prebiotics such as chicory root, which may support healthy gastrointestinal tract function, promote beneficial short-chain fatty acid production by healthy gut microbiota, and provides functional prebiotics that may help the growth of Bifidobacteria and Lactobacillus species in gut microflora.

DHA

With FDA approved claims to promote cardiovascular health, brain health and eye health in normal range at all stages of life. DHA is a structural component of human brain and retina of the eye. DHA may also positively influence the healthy gut-brain axis, promote intestinal wall integrity and support immune health of the body.

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Innovation meets nature.

Our L-Biome, equipped with dual-cap technology, ensures that you get the optimum dosage of these ingredients in a safe and effective way. The DHA is housed in the external part of the capsule for immediate absorption, while the other ingredients are safely encased inside, gradually releasing their potential benefits over time.

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How and when to use

The L-Biome could be used daily by anyone aged 18-80. Best use is to take after doing one of Prolon’s Fasting Nutrition Products: 5-Day Fasting Mimicking Diet, 1-Day Reset Nutrition, Fasting Bar or Fasting Shake. You can stop and restart at any time. If you have a health condition, consult with your doctor before taking the L-Biome. Do not take the L-Biome if you have allergies to any of its ingredients.

With Prolon’s L-Biome, you're not just choosing a supplement, you're choosing a partner in your longevity and healthy aging journey. While we're continuously researching to further advance our understanding of longevity, we're committed to providing you with the best of what science and nature offer today.

Some Morinaga B-3 Select References:

  • Minami, J.I., Kondo, S., Yanagisawa, N., et al., 2015. Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial. Journal of Nutritional Science, 4.

  • Minami, J., Iwabuchi, N., Tanaka, M., et al., 2018. Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: a randomized, double-blind, placebo-controlled trial. Bioscience of Microbiota, Food and Health, pp.18-001.

  • Inoue T, Kobayashi Y, Mori N, Sakagawa M, et al., 2018. Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects. Benef Microbes. 2018 Dec 7;9.


LactoB HN001 Lactobacillus rhamnosus strain: Some Select References:

  • González-Hernández LA, Jave-Suarez LF, Fafutis-Morris M, Montes-Salcedo KE, Valle-Gutierrez LG, Campos-Loza AE, Enciso-Gómez LF, Andrade-Villanueva JF (2012) Synbiotictherapy decreases microbial translocation and inflammation and improves immunological status in HIV-infected patients: a double-blind randomized controlled pilot trial. Nutr J 11:90.

  • Mokkala K, Pussinen P, Houttu N, Koivuniemi E, Vahlberg T, Laitinen K. (2018) The impact of probiotics and n-3 long-chain polyunsaturated fatty acids on intestinal permeability inpregnancy: a randomised clinical trial. Beneficial Microbes 9(2): 199-208

  • Kruger MC, Fear A, Chua WH, Plimmer GG, Schollum LM (2009) The effect of Lactobacillus rhamnosus on mineral absorption and bone health in growing male and ovariectomised female rats. Dairy Science & Technology 89:219-231.

  • Tannock GW, Taylor C, Lawley B, Loach D, Gould M, Dunn AC, McLellan AD, Black MA, McNoe L, Dekker J, Gopal P, Collett MA (2014) Altered transcription of murine genes induced in the small bowel by administration of probiotic strain Lactobacillus rhamnosus HN001. Applied and Environmental Microbiology 80:2851-2859

  • Miller LE, Ouwehand AC (2013) Probiotic supplementation decreases intestinal transit time: Meta- HN019, analysis of randomized controlled trials. World Journal of Gastroenterology 19:4718-4725


Inulin / Fructooligosaccharide Select References:

  • Shah BR, Li B, Al Sabbah H, Xu W, Mráz J. Effects of prebiotic dietary fibers and probiotics on human health: With special focus on recent advancement in their encapsulated formulations. Trends Food Sci Technol. 2020 Aug;102:178-192.

  • den Besten G., van Eunen K., Groen A.K., Venema K., Reijngoud D.-J., Bakker B.M. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research. 2013;54(9):2325–2340.

  • Dewulf E., Cani P., Claus S., Neyrinck A., Puylaert P., Glenn G.…Delzenne N. INULIN-TYPE fructans with prebiotic properties lessen endotoxemia and modulate host metabolism by changing gut microbiota composition in obese women: 749 accepted poster. Obesity Facts. 2012;5:200–201.

  • Dewulf E.M., Cani P.D., Neyrinck A.M., Possemiers S., Van Holle A., Muccioli G.G.…Sohet F.M. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. The Journal of Nutritional Biochemistry. 2011;22(8):712–722.

  • Nicolucci A.C. Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity. Gastroenterology. 2017;153(3):711–722



BASF Algal Oil DHA (200 mg dose): Select References:

  • Costantini L, Molinari R, Farinon B, Merendino N. Impact of Omega-3 Fatty Acids on the Gut Microbiota. Int J Mol Sci. 2017 Dec 7;18(12):2645 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751248/

  • Jayapala H, Lim SY. N-3 Polyunsaturated Fatty Acids and Gut Microbiota. Comb Chem High Throughput Screen. 2022 Jul 1. doi: https://pubmed.ncbi.nlm.nih.gov/35786331/

  • Rousseau G. Microbiota, a New Playground for the Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Diseases. Mar Drugs. 2021 Jan 23;19(2):54. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931107/

  • Stillwell W, Wassall SR. Docosahexaenoic acid: membrane properties of a unique fatty acid. Chem Phys Lipids. 2003;126(1):1-27.

  • Serhan CN. Novel Pro-Resolving Lipid Mediators in Inflammation Are Leads for Resolution Physiology. Nature. 2014 Jun 5; 510(7503): 92–101.

  • Kotani S, Sakaguchi E, Warashina S, et al. Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neurosci Res 2006;56(2):159-64.

  • Innes JK, Calder PC. Marine Omega-3 (N-3) Fatty Acids for Cardiovascular Health: An Update for 2020. Int J Mol Sci. 2020 Feb 18;21(4):1362.

  • SanGiovanni JP, Chew EY. The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res. 2005;24(1):87-138

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